Treatment for depression fractures of posterolateral tibial plateau through superior fibular head approach / 中国骨伤

OBJECTIVE@#To evaluate surgical method and clinical efficacy for the treatment of depression fractures of posterolateral tibial plateau through superior fibular head approach.@*METHODS@#Eleven patients with depression fractures of posterolateral tibial plateau through superior fibular head approach were treated from October 2013 to December 2016, including 9 males and 2 females with an average age of 39.7 years old ranged from 25 to 60 years old. The time from injure to operation ranged from 4 to 10 days with an average of 6.5 days. All fractures were closed fracture. Incision healing, tibial plateau varus angles and posterior slope angle were measured through X-rays immediately after operation and latest follow-up. At final follow-up, HSS score of knee joint were used to evaluate clinical effects.@*RESULTS@#Eleven patients were followed up ranged from 11 to 13 months ranged from 55 to 90 min. All incisions were healed at stage I. Fracture healing time ranged from 7 to 12 weeks. There were no significant differences of tibial plateau varus angles and posterior slope angles comparing between immediately opertaion and latest follow-up (<0.05). At the final follow up, HSS scores ranged from 80 to 93 points, 6 cases were excellent and 5 moderate.@*CONCLUSIONS@#Depression fractures of posterolateral tibial plateau through superior fibular head approach has advantages of simple operation, less invasive, benefit for recovery of knee joint function, and could receive clinical effects.

Spectrum-effect relationship in antioxidant activity of Ligustri Lucidi Fructus based on DPPH, ABTS and FRAP assays / 中国中药杂志

Characteristic chromatogram of Ligustri Lucidi Fructus which were processed by heat treatment with different temperatures and times was developed by HPLC. DPPH, ABTS and FRAP assays were performed to determine the antioxidant activity. The spectrum-effect correlation was studied using Partial Least Squares(PLS)to explore the active ingredients of Ligustri Lucidi Fructus by investigating the relationship between HPLC spectrum and antioxidant activity. S1, S2, S15, S24, S27, S29, S32, S33 and S35 were characteristic compounds in 35 matching characteristic chromatograms which were positive relationship with scavenging DPPH free radical activity. S1, S2, S5, S8, S16, S27 and S33 were significantly positively related to scavenge ABTS free radical activity. S12, S20, S22, S28, S30, S31, S32 and S34 were significantly positively related to restore Fe³⁺ activity. Among the chromatographic peaks, S1, S2, S27 and S33were positively related to scavenge DPPH free radical and ABTS free radical activity, and S32 was positively related to scavenge DPPH free radical and restore Fe³⁺ activity. S3, S19, S21, S22, S23, S33 and S34 were determined as salidroside, luteolin-7-O-glucoside, specnuezhenide, oleuropein, ligustroflavone, luteolin andapigenin, respectively. The results showed that although specnuezhenide and salidroside were stipulated index compounds to evaluate the quality of Ligustri Lucidi Fructus, the Ligustri Lucidi Fructus pharmcodynamic effect did not depend on the contents of those index components. The quality of traditional Chinese medicines(TCMs)should be determined by the compound groups associated with pharmcodynamic effect.